Protein name:
Transcription initiation factor TFIID subunit 1;
Alternative:
TBP-associated factor 250 kDa(p250);Cell cycle gene 1 protein;Transcription initiation factor TFIID 250 kDa subunit(TAF(II)250;TAFII-250;TAFII250);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B.
Function:
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MGPGWAGLLQ | DKGGGSPSVV | MSDTDSDEES | AGGGPFSLTG | FLFGNINGAG |
100:
QLEGESVLDD | ECKKHLAGLG | ALGLGSLITE | LTANEELSGS | DGALVNDEGW |
150:
IRSREDAVDY | SDINEVAEDE | SRRYQQTMGS | LQPLCHTDYD | EDDYDADCED |
200:
IDCKLMPPPP | PPPGPLKKEK | DQDDITGVSE | DGEGIILPSI | IAPSSLASEK |
250:
VDFSSSSDSE | SEMGPQDAAQ | SESKDGQLTL | PLAGIMQHDA | TKLLPSVTEL |
300:
FPEFRPGKVL | RFLRLFGPGK | NVPSVWRSAR | RKRKKKHREL | IQEGQVQEEE |
350:
CSVELEVNQK | SLWNYDYAPP | PLPDQCLSDD | EITMMAPVES | KFSQSTGDTD |
400:
KVMDTKPRVA | EWRYGPARLW | YDMLGVPEDG | SGFDYGFKMK | KTEHESTIKC |
450:
NIMKKLRKLE | ENSGVDLLAD | ENFLMVTQLH | WEDDIIWDGE | DVKHKGTKPQ |
500:
RASLAGWLPS | SMTRNAMAYN | VQQGFTATLD | DDKPWYSIFP | IDNEDLVYGR |
550:
WEDNIIWDAQ | NMPRILEPPV | LTLDPNDENL | ILEIPDEKEE | ATSNSPSKEN |
600:
KKESSLKKSR | ILLGKTGVIK | EEPQQNMSQP | EVKDPWNLSN | DEYYYPKQQG |
650:
LRGTFGGNII | QHSIPAVELR | QPFFPTHMGP | IKLRQFHRPP | LKKYSFGALS |
700:
QPGPHSVQPL | LKHIKKKAKM | REQERQASGG | GEMFFMRTPQ | DLTGKDGDLI |
750:
LAEYSEENGP | LMMQVGMATK | IKNYYKRKPG | KDPGAPDCKY | GETVYCHTSP |
800:
FLGSLHPGQL | LQAFENNLFR | APIYLHKMPE | SDFLIIRTRQ | GYFIRELVDI |
850:
FVVGQQCPLF | EVPGPNSKRA | NTHIRDFLQV | FIYRLFWKSK | DRPRRIRMED |
900:
IKKAFPSHSE | SSIRKRLKLC | ADFKRTGMDS | NWWVLKSDFR | LPTEEEIRAM |
950:
VSPEQCCAYY | SMIAAEQRLK | DAGYGEKSFF | APEEENEEDF | QMKIDDEVRT |
1000:
APWNTTRAFI | AAMKGKCLLE | VTGVADPTGC | GEGFSYVKIP | NKPTQQKDDK |
1050:
EPQPVKKTVT | GTDADLRRLS | LKNAKQLLRK | FGVPEEEIKK | LSRWEVIDVV |
1100:
RTMSTEQARS | GEGPMSKFAR | GSRFSVAEHQ | ERYKEECQRI | FDLQNKVLSS |
1150:
TEVLSTDTDS | SSAEDSDFEE | MGKNIENMLQ | NKKTSSQLSR | EREEQERKEL |
1200:
QRMLLAAGSA | AAGNNHRDDD | TASVTSLNSS | ATGRCLKIYR | TFRDEEGKEY |
1250:
VRCETVRKAT | VIDAYVRIRT | TKDEEFIRKF | ALFDEQHREE | MRKERRRIQE |
1300:
QLRRLKRNQE | KEKLKGPPEK | KPKKMKERPD | LKLKCGACGA | IGHMRTNKFC |
1350:
PLYYQTNAPP | SNPVAMTEEQ | EEELEKTVIH | NDNEELIKVE | GTKIVLGKQL |
1400:
IESADEVRRK | SLVLKFPKQQ | LPPKKKRRVG | TTVHCDYLNR | PHKSIHRRRT |
1450:
DPMVTLSSIL | ESIINDMRDL | PNTYPFHTPV | NAKVVKDYYK | IITRPMDLQT |
1500:
LRENVRKRLY | PSREEFREHL | ELIVKNSATY | NGPKHSLTQI | SQSMLDLCDE |
1550:
KLKEKEDKLA | RLEKAINPLL | DDDDQVAFSF | ILDNIVTQKM | MAVPDSWPFH |
1600:
HPVNKKFVPD | YYKVIVSPMD | LETIRKNISK | HKYQSRESFL | DDVNLILANS |
1650:
VKYNGPESQY | TKTAQEIVNV | CHQTLTEYDE | HLTQLEKDIC | TAKEAALEEA |
1700:
ELESLDPMTP | GPYTPQPPDL | YDNNTSLSVS | RDASVYQDES | NLSVLDIPSA |
1750:
TSEKQLTQEG | GDGDGDLADE | EEGTVQQPQA | SVLYEDLLMS | EGEDDEEDAG |
1800:
SDEEGDNPFF | AIQLSESGSD | SDVESGSLRP | KQPRVLQENT | RMGMENEESM |
1850:
MSYEGDGGDA | SRGLEDSNIS | YGSYEEPDPK | SNTQDTSFSS | IGGYEVSEEE |
1891:
EDEEEQRSGP | SVLSQVHLSE | DEEDSEDFHS | IAGDTDLDSD | E

Vaild Sequence:
Related Databases
Uniprot: