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Index > Protein center > Taf1(Gene name) > Mouse
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  • Taf1 (Gene name),
  • Transcription initiation factor TFIID subunit 1 (Protein name ),  TAF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Taf1(Ccg1);
    Protein name:
    Transcription initiation factor TFIID subunit 1;
    Alternative:
    TBP-associated factor 250 kDa(p250);Cell cycle gene 1 protein;Transcription initiation factor TFIID 250 kDa subunit(TAF(II)250;TAFII-250;TAFII250);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B.
    Function:
    Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1891
    Sequence:
    50:
    MGPGWAGLLQ | DKGGGSPSVV | MSDTDSDEES | AGGGPFSLTG | FLFGNINGAG | 
    100:
    QLEGESVLDD | ECKKHLAGLG | ALGLGSLITE | LTANEELSGS | DGALVNDEGW | 
    150:
    IRSREDAVDY | SDINEVAEDE | SRRYQQTMGS | LQPLCHTDYD | EDDYDADCED | 
    200:
    IDCKLMPPPP | PPPGPLKKEK | DQDDITGVSE | DGEGIILPSI | IAPSSLASEK | 
    250:
    VDFSSSSDSE | SEMGPQDAAQ | SESKDGQLTL | PLAGIMQHDA | TKLLPSVTEL | 
    300:
    FPEFRPGKVL | RFLRLFGPGK | NVPSVWRSAR | RKRKKKHREL | IQEGQVQEEE | 
    350:
    CSVELEVNQK | SLWNYDYAPP | PLPDQCLSDD | EITMMAPVES | KFSQSTGDTD | 
    400:
    KVMDTKPRVA | EWRYGPARLW | YDMLGVPEDG | SGFDYGFKMK | KTEHESTIKC | 
    450:
    NIMKKLRKLE | ENSGVDLLAD | ENFLMVTQLH | WEDDIIWDGE | DVKHKGTKPQ | 
    500:
    RASLAGWLPS | SMTRNAMAYN | VQQGFTATLD | DDKPWYSIFP | IDNEDLVYGR | 
    550:
    WEDNIIWDAQ | NMPRILEPPV | LTLDPNDENL | ILEIPDEKEE | ATSNSPSKEN | 
    600:
    KKESSLKKSR | ILLGKTGVIK | EEPQQNMSQP | EVKDPWNLSN | DEYYYPKQQG | 
    650:
    LRGTFGGNII | QHSIPAVELR | QPFFPTHMGP | IKLRQFHRPP | LKKYSFGALS | 
    700:
    QPGPHSVQPL | LKHIKKKAKM | REQERQASGG | GEMFFMRTPQ | DLTGKDGDLI | 
    750:
    LAEYSEENGP | LMMQVGMATK | IKNYYKRKPG | KDPGAPDCKY | GETVYCHTSP | 
    800:
    FLGSLHPGQL | LQAFENNLFR | APIYLHKMPE | SDFLIIRTRQ | GYFIRELVDI | 
    850:
    FVVGQQCPLF | EVPGPNSKRA | NTHIRDFLQV | FIYRLFWKSK | DRPRRIRMED | 
    900:
    IKKAFPSHSE | SSIRKRLKLC | ADFKRTGMDS | NWWVLKSDFR | LPTEEEIRAM | 
    950:
    VSPEQCCAYY | SMIAAEQRLK | DAGYGEKSFF | APEEENEEDF | QMKIDDEVRT | 
    1000:
    APWNTTRAFI | AAMKGKCLLE | VTGVADPTGC | GEGFSYVKIP | NKPTQQKDDK | 
    1050:
    EPQPVKKTVT | GTDADLRRLS | LKNAKQLLRK | FGVPEEEIKK | LSRWEVIDVV | 
    1100:
    RTMSTEQARS | GEGPMSKFAR | GSRFSVAEHQ | ERYKEECQRI | FDLQNKVLSS | 
    1150:
    TEVLSTDTDS | SSAEDSDFEE | MGKNIENMLQ | NKKTSSQLSR | EREEQERKEL | 
    1200:
    QRMLLAAGSA | AAGNNHRDDD | TASVTSLNSS | ATGRCLKIYR | TFRDEEGKEY | 
    1250:
    VRCETVRKAT | VIDAYVRIRT | TKDEEFIRKF | ALFDEQHREE | MRKERRRIQE | 
    1300:
    QLRRLKRNQE | KEKLKGPPEK | KPKKMKERPD | LKLKCGACGA | IGHMRTNKFC | 
    1350:
    PLYYQTNAPP | SNPVAMTEEQ | EEELEKTVIH | NDNEELIKVE | GTKIVLGKQL | 
    1400:
    IESADEVRRK | SLVLKFPKQQ | LPPKKKRRVG | TTVHCDYLNR | PHKSIHRRRT | 
    1450:
    DPMVTLSSIL | ESIINDMRDL | PNTYPFHTPV | NAKVVKDYYK | IITRPMDLQT | 
    1500:
    LRENVRKRLY | PSREEFREHL | ELIVKNSATY | NGPKHSLTQI | SQSMLDLCDE | 
    1550:
    KLKEKEDKLA | RLEKAINPLL | DDDDQVAFSF | ILDNIVTQKM | MAVPDSWPFH | 
    1600:
    HPVNKKFVPD | YYKVIVSPMD | LETIRKNISK | HKYQSRESFL | DDVNLILANS | 
    1650:
    VKYNGPESQY | TKTAQEIVNV | CHQTLTEYDE | HLTQLEKDIC | TAKEAALEEA | 
    1700:
    ELESLDPMTP | GPYTPQPPDL | YDNNTSLSVS | RDASVYQDES | NLSVLDIPSA | 
    1750:
    TSEKQLTQEG | GDGDGDLADE | EEGTVQQPQA | SVLYEDLLMS | EGEDDEEDAG | 
    1800:
    SDEEGDNPFF | AIQLSESGSD | SDVESGSLRP | KQPRVLQENT | RMGMENEESM | 
    1850:
    MSYEGDGGDA | SRGLEDSNIS | YGSYEEPDPK | SNTQDTSFSS | IGGYEVSEEE | 
    1891:
    EDEEEQRSGP | SVLSQVHLSE | DEEDSEDFHS | IAGDTDLDSD | E
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    E8802h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    E8802m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    U8802h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    U8802m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    P8802Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Transcription initiation factor TFIID subunit 1
    Cat.:
    P8802Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Transcription initiation factor TFIID subunit 1
    Monoclonal Antibody for Mouse Transcription initiation factor TFIID subunit 1
    Protein for Mouse Transcription initiation factor TFIID subunit 1
    Protein for Mouse Transcription initiation factor TFIID subunit 1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-1891
      strain: C57BL/6.
      strain: Czech II.
      tissue: Brain.
      tissue: Mammary tumor.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-280 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 849-1237 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401 AND 1143-1891
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Corpora quadrigemina.
      tissue: Head.
      tissue: Hippocampus.
      tissue: Spleen.
    4. 4.
      "TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin."
      Saadane N. , Alpert L. , Chalifour L.E.
      Am. J. Physiol.276:H803-H814(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-370; 841-876 AND 1199-1488
      strain: CD-1.
      tissue: Heart.
    5. 5.
      "HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes."
      Weissman J.D. , Brown J.A. , Howcroft T.K. , Hwang J. , Chawla A. , Roche P.A. , Schiltz L. , Nakatani Y. , Singer D.S.
      Proc. Natl. Acad. Sci. U.S.A.95:11601-11606(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-1306
      tissue: Spleen.
    6. 6.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-565;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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